IL6 and thrombotic disease: A second possible explanation is that musculoskeletal pain is a sequela of a COVID-19 inflammatory cytokine storm, wherein a burst of pro-inflammatory cytokines, such as interleukin-6, is produced [23, 24] Thirdly, muscular pain, in at least some cases, may reflect poor vascularization of muscles related to COVID-19 associated thromboses [25, 26].