Both univariable and multivariable analyses showed that DFS was significantly lower in patients with TSR-high tumours compared to TSR-low tumours (univariable HR = 2.12 (CI 1.06–4.23, p = 0.033); multivariable(adjusted for BRAF status and tumour differentiation grade)HR = 2.19 (CI 1.09–4.42, p = 0.028); multivariable (adjusted for microsatellite status and tumour differentiation grade) HR = 2.20 (CI 1.10–4.44, p = 0.027)) (Table 2). Here, BRAF is linked to neoplasm.