In AGS and HGC27 cell lines, ANGPTL3 expression was significantly hindered under METTL3 and markedly strengthened under si-METTL3, while cell growth and migration changes were opposite to ANGPTL3 levels but consistent with ANGPTL3 mRNA m6A levels, suggesting that ANGPTL3 antagonized STAD tumors. Here, METTL3 is linked to gastric adenocarcinoma.