Higher EGFR expression was confirmed in this study on human esophageal cancer cells (KYSE-30 and EC109) by western blot analysis and significant cellular association of GE11-GO (average size of ∼196 nm with an average zeta potential of −41.2 mV) was demonstrated on these cancer cells (>3-fold) compared with normal human esophageal epithelial HEEC cells (Jiang et al., 2018). This evidence concerns the gene EGFR and esophageal cancer.