Inclusive of all patients, regardless of the status of the oncogenic mutations, the correlation between total cfDNA and PIK3CA and TP53 AF was weak (Pearson correlation coefficient R = 0.34, p < 0.001) and non-existent (R = 0.055, p = 0.48), respectively (Fig. 3a, c). This evidence concerns the gene PIK3CA and atrial fibrillation.