If the correlation analysis included only patients with PIK3CA or TP53 mutations (AF > 0) identified by liquid biopsy, the correlation coefficient increased to 0.53 (p < 0.001, Fig. 3b) and 0.43 (p = 0.033, Fig. 3d) for PIK3CA and TP53, respectively. Here, PIK3CA is linked to atrial fibrillation.