Compared with SPP1-treated control mice (n = 4 each), the numbers of induced anagen HFs were significantly reduced both in K14-Cre;Cd44fl/fl (n = 6) (Fig. 4j) and in induced K14-CreERT;Cd44fl/fl (n = 3) mice (Fig. 4k). This evidence concerns the gene SPP1 and Hand-foot syndrome.