The subsequent IPA analysis showed that inhibition of matrix metalloproteases (MMP) and rheumatoid arthritis-related pathway were observed in profile # 9, while adipogenesis-related pathways, like PPARα/RXRα activation, apelin adipocyte pathway, white adipose tissue browning pathways and FXR/RXR activation were found in profile # 41 and profile # 18. Here, NR1H4 is linked to rheumatoid arthritis.