This research aims at exploring the relationship between SLE-related autoantibodies, including anti-dsDNA, anti-Sm, anti-ribosomal P protein (anti-P), anti-chromatin, anti-SSA/Ro60 (anti-Ro60), anti-SSA/Ro52 (anti-Ro52), anti-SSB, anti-centromere and anti-SmRNP antibodies, and clinicopathological features such as sex, age, disease activity, serological results and clinical manifestations in Chinese patients with new-onset SLE by retrospective cohort study. The gene discussed is OCA2; the disease is systemic lupus erythematosus.