For instance, given the tree of patient sample AML-38-002, TreeMHN successfully identifies the two relapse events (Root → NPM1 → IDH2 → PTPN11 and Root → NPM1 → IDH1 → FLT3 in AML-38-003) in the top 5% most probable mutational events. Here, PTPN11 is linked to acute myeloid leukemia.