In the management of cervical cancer, the reduction of ROS could attenuate the cytotoxicity of DOX [96], while the upregulation of GSH-related genes represented by glutathione S-transferases M1 and Alpha 1-3 (GSTM1 and GSTA1-3), enzyme activities and transporter proteins may be crucial factors leading to the development of DOX resistance in cervical cancer cells [97]. The gene discussed is GSTA1; the disease is cervical cancer.