The main mechanisms by which anthracyclines lead to iron disorders include mediating the upregulation of transferrin receptor (TfR) to allow more iron into the cell [16] and triggering the direct inactivation of ferritin and the indirect downregulation of ferritin due to the inactivation of iron regulatory proteins 1 and 2 (IRP1 and IRP2) [17]. The gene discussed is ACO1; the disease is iron metabolism disease.