Univariate Cox proportional hazard model identified the following as significant factors for BCR: initial PSA ≥ 7.6 ng/mL (p = 0.0319), extra-prostatic extension (EPE) positive (p < 0.0001), RM+ (p < 0.0001), SV+ (p < 0.0001), Pathological Grade Group ≥ 3 (p < 0.0001), lymph node metastases (p = 0.013), radiological tumor location at PZ (p = 0.002), and PI-RADS category 5 (p < 0.0001) (Table 3). Here, KLK3 is linked to neoplasm.