E3 ubiquitin ligases are the most abundant, especially the CULLIN (CUL) protein family (CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, CUL7, and CUL9), which specifically recognizes substrates and plays an important role in the regulation of protein homeostasis [7], and E3 ubiquitin ligases mutations are always involved in the occurrence and progression of cancers [8]. Here, PRKN is linked to cancer.