The associations among PR and these proteins were explored by TCGA data bank, the data demonstrated that there was positive correlation between PR and TRPS1 in endometrial cancer (R = 0.42) and the coefficient of PR and TRPS1 was the highest in breast cancer (R = 0.31), implying that there might exist potential interactions between PR and TRPS1 (Fig. 4B and Supplementary Fig. 6). Here, PGR is linked to breast carcinoma.