PGR and breast cancer: According to the analysis of GEPIA, the findings indicated that PR positively correlated with TRPS1 (R = 0.42) and TRPS1 positively correlated with HDAC2 (R = 0.44) in EC, while in breast cancers, the expressions of PR and TRPS1 were positively correlated (R = 0.31), the association between TRPS1 and HDAC2 was not significant (R = 0.058), which may be owing to different cell contexts (Fig. 4B, G).