TRPS1 and cancer: Likewise, Cornelissen made a similar point that several cancer cell lines showed reduced growth both in vitro and in vivo upon TRPS1 knockdown [42, 61, 66], and in other settings, silencing TRPS1 seemed to be promoting tumor growth [44], further implying that TRPS1 expression was essential for proliferation and the effects of TRPS1 appeared to be context dependent.