GATA1/2/3 was necessary for the differentiation of mesoderm and ectoderm, such as the nervous and hematopoiesis systems, GATA4/5/6 was essential for the development of mesoderm and endoderm, including cardiovascular embryogenesis [36, 37], and TRPS1 was reported to modulate a number of major cellular processes [38–41], such as tumor cell proliferation and apoptosis [42–44]. This evidence concerns the gene GATA4 and neoplasm.