There were 5 common mtDNAs shared with anxiety and depression in MiWAS (Fig. 3), namely m.10915T>C(MT-ND4), m.3010G>A(MT-RNR2), m.9899T>C(MT-CO3), m.15257G>A(MT-CYB) and m.4580G>A(MT-ND2). Here, MT-ND4 is linked to major depressive disorder.