A total of 7 mtDNA–CRP associations were detected for anxiety (Table 3) (Fig. 2), such as m.3915G>A(MT-ND1) with self-reported anxiety in all subjects (P value = 6.59 × 10−3), m.12633C>A (MT-ND5; P value = 4.90 × 10−3), and m.11467A>G (MT-ND4; P value = 9.39 × 10−3) with self-reported anxiety in male participants. Here, CRP is linked to Anxiety.