Given that diffuse fibrosis is commonly seen in chronic heart diseases such as hypertensive heart disease,[42] aortic stenosis,[43] HCM,[44] and some systemic clinical conditions evolving with HF,[45, 46] this finding raises the possibility that FBLN7 may function in various chronic diseases that can lead to diffuse myocardial fibrosis. This evidence concerns the gene FBLN7 and aortic stenosis.