For instance, fibulin 1(FBLN1) participates in vascular remodeling[19] and pulmonary fibrosis;[20, 21] fibulin 2 (FBLN2) is involved in cardiac fibrosis;[22] fibulin 3 (FBLN3) participates in vascular remodeling;[23] and fibulin 5 is associated with cutaneous fibrosis[24] and hepatic fibrosis.[25] Due to their similar amino acid sequences and domain structures, members of the fibulin family are likely to exhibit comparable biological functions. This evidence concerns the gene FBLN1 and Hepatic fibrosis.