For instance, fibulin 1(FBLN1) participates in vascular remodeling[19] and pulmonary fibrosis;[20, 21] fibulin 2 (FBLN2) is involved in cardiac fibrosis;[22] fibulin 3 (FBLN3) participates in vascular remodeling;[23] and fibulin 5 is associated with cutaneous fibrosis[24] and hepatic fibrosis.[25] Due to their similar amino acid sequences and domain structures, members of the fibulin family are likely to exhibit comparable biological functions. Here, EFEMP1 is linked to Hepatic fibrosis.