The genes implicated in the pathogenesis of HCC include the regulation or modulation of: (1) DNA damage response (p53); (2) growth inhibition and apoptosis mannose 6‐phosphate (M6P), Mother against decapentalpegic homolog 2 (SMAD2); (3) cell cycle control (Retinoblastoma transcriptional corepressor 1 (RB)1, cyclinD) and (4) cell–cell interactions (Adenomatous polyposis coli (APC; also known as deleted in polyposis 2.5) and E‐cadherin).66 This evidence concerns the gene RB1 and hepatocellular carcinoma.