The acute-phase proteins serum amyloid A1 (SAA1) and A2 (SAA2) interacted with multiple HDL-associated apolipoproteins, including ApoD, which we have previously observed to interact with SARS-CoV-2 spike using immunoprecipitation-MS in plasma from patients with COVID-19 (1) (Fig. 1A). This evidence concerns the gene SAA1 and COVID-19.