This is further emphasized by the early relocalisation of PABPC1 to the nucleus of Δ22 infected cells at a time when cellular mRNA degradation is reduced rather than enhanced compared to Wt infection (Fig 6B) [4], suggesting that mRNA and hence PABPC1 retention in the nucleus can be uncoupled from excessive cellular mRNA degradation. The gene discussed is PABPC1; the disease is infection.