Region-based subgroup analysis demonstrated that there was a poor correlation between hs-CRP levels and recurrent stroke whether in the subgroup of Asia [RR = 1.02, 95% CI (1.00 ~ 1.04); p = 0.017] and the subgroup of non-Asian regions [RR = 1.03, 95% CI (1.01 ~ 1.05), p = 0.002]. This evidence concerns the gene CRP and Stroke.