miR-141-3p mimics can inhibit the up-regulation of necroptosis-related molecules and the interaction of RIPK1 and RIPK3 in LPS-induced Caco-2 cells (48), suggesting that miR-141-3p protects IECs from cellular injury by inhibiting RIPK1-mediated necroptosis and inflammatory cytokine release, providing a perspective for exploring the pathogenesis of NEC. Here, RIPK1 is linked to necrotizing enterocolitis.