The TBA level of the HSP with AI group was significantly higher than that of the HSP group (6.98 ± 3.38 vs. 1.91 ± 0.78, P < 0.0001), and there were no differences between the two groups in TBIL, DBIL, γ-GGT, and albumin (P > 0.05). The gene discussed is ALB; the disease is hereditary spastic paraplegia.