SLC26A6 and Hyperoxaluria: The mechanism may be that in SLC26A6 gene KO mice, due to the deficiency of SLC26A6-mediated oxalate secretion in the intestine, the net absorption of oxalate in the intestine increases, the concentration of oxalate in the plasma increases, and more oxalate is excreted from the urine, causing hyperoxaluria, which leads to the occurrence of oxalate stones.