PSEN1 and Alzheimer disease: It has been reported that APP is expressed in the normal mouse pancreas, and in the APP/PS1 mouse model of AD, APP is overexpressed within pancreatic islets.29 There are also extensive amyloid deposits in the pancreas of 8-mo-old APP/PS1 transgenic mice.30 In addition, transgenic mice overexpressing both amyloid beta-protein and perlecan in pancreatic acinar cells.31,32 We detected Aβ deposition, in the pancreas of 3xTg AD mice, using thioflavin staining.