APP and Alzheimer disease: The increase in intracellular Ca2+ generates Ca2+-induced Ca2+ release by affecting the open-state probability of the IP3R or RyR channels.43 As a highly innervated organ, pancreas shares a number of pathophysiologic similarities to Aβ deposition in the brain .20 Our results show that Aβ deposits can be detected in both pancreatic acinar cells and hippocampal neurons in aged APP AD model mice (Figure 5).