Considering that the pancreas shares a number of striking pathophysiologic similarities in Aβ deposition compared to that in brain, and AD also can cause Aβ deposition in the mouse pancreas upon overexpression of human APP, suggesting that Aβ deposits may occur in other organs than the brain.20 Therefore, we hypothesized that Aβ channels may mediate these spontaneous Ca2+ oscillations in aged 3xTg AD mice. The gene discussed is APP; the disease is Alzheimer disease.