ROCK1 is known as a substantial modulator of focal adhesion formation, cancer cell motility, and invasion.21 In this regard, growing evidence indicated the downregulation of ROCK1 by miR-193a and miR-340 in BC,16,22 miR-335 in osteosarcoma,23 miR-148a in gastric cancer,24 and miR-1280 in bladder cancer­25 could considerably suppress the cell migration, invasion, and metastasis manner of cancer cells. This evidence concerns the gene ROCK1 and osteosarcoma.