In this connection, it was reported that miR-520c and miR-373 enhance migration and invasion of cancer cells by targeting CD44 in BC.29,30 Besides, it was suggested that cancer cells that undergo EMT gain stem cell-like properties and represent CD44 overexpression.31 On the other hand, observation of EMT phenotype in cancer cells frequently leads to more resistance to chemotherapy.32 The involvement of CD44 in cancer progression provides that CD44 may be a suitable molecular target for cancer target therapy. The gene discussed is CD44; the disease is cancer.