PTGS2 and mucositis: Limited studies have reported benefits of steroids against mTOR-induced oral ulcers.23 Animal studies also reported that induction of mucositis was associated with changes in inflammatory pathways and nitric oxide metabolism.24 Available literature suggests that the transcription factor NF-κB plays a crucial role in the formation of mucositis.25 This may result in increasing cyclooxygenase-2 activity, leading to accumulation of submucosal fibroblasts and increased prostaglandin production.