SMAD7 and oral mucositis: It could soothe the pain of oral mucositis ulcers.31 Oral cryotherapy is the other treatment for preventing and reducing the severity of chemotherapy-induced oral mucositis.32 In this method, practitioners chill the oral cavity by using ice, ice cream, or cold water to reduce blood flow and thereby reduce the local effects of the chemotherapy agents on oral mucosa.33 On the other side, Smad7 could suppress NF-κB and TGFβ, causing a decrease in apoptosis and inflammation while increasing epithelial migration.