As a result, we hypothesize that T2D patient carriers of these risk allele variants have a greater risk to develop AD.Likely, the functional annotation of non-coding variants revealed three top-ranked SNPs rs1544210, rs12679834, and rs515071 located, respectively, in HHEX, LPL, and ANK1 gene. This evidence concerns the gene LPL and type 2 diabetes mellitus.