MADD gene, also known as IG20, plays a critical role in the development of glucose intolerance (Dupuis et al., 2010; Hu et al., 2010; Strawbridge et al., 2011; Wagner et al., 2011) and AD (Del Villar and Miller, 2004; Hassan et al., 2021). The gene discussed is MADD; the disease is Alzheimer disease.