Moreover, the release of acetylcholine (Ach) is enhanced by electrical stimulation of the VN, which acts on α7 nicotinic acetylcholine receptors of macrophages to inhibit the release of proinflammatory cytokine, such as TNF and attenuate the serum TNF response induce by LPS after stroke-induced GM translocation (199). The gene discussed is TNF; the disease is stroke disorder.