A high RS is negatively associated with infiltration of memory B cells, activated memory CD4+ T cells, CD8+ T cells, aDCs, M0 and M1 macrophages, activated NK cells, plasma cells, Tfh, Treg cells, and positively associated with infiltration of M2 macrophages, resting memory CD4+ T cells, resting DCs, resting mast cells, naive B cells, and eosinophils.A low RS is associated with high expression of 36 ICs, and with enrichment of cell cycle, cytokine-cytokine receptor interaction, chemokine signaling pathway, primary immunodeficiency, and T cell receptor signaling pathway. Here, CD8A is linked to inborn error of immunity.