Furthermore, this study showed a cytotoxicity decrease in CD8+ T cells against TNBC cells treated with anti-PD-L1 inhibitor and cultured under conditioned media derived from TAMs with MALAT1 and HOTAIR silencing, indicating the role of both lncRNAs as tumor-extrinsic negative modulators of the antitumoral immune response in BC (109) (Figure 3). This evidence concerns the gene CD274 and breast cancer.