iCAF were able to produce high levels of IL-6, IL-11, leukemia inhibitory factor (LIF), and chemokines (CXCL1, CXCL2) while myCAF, detected closer to the tumor lesions, expressed high levels of α-SMA and ACTA2 genes, CTGF and COL1A1 (TGF-β-response genes) (51). The gene discussed is ACTA2; the disease is neoplasm.