By KEGG analysis, ECM-receptor interaction, PI3K-Akt signaling pathway, Cytokine-cytokine receptor interaction were the major upregulated biological pathways in the C1 group, and Phagosome, Cell adhesion molecules (CAMs), and Epstein-Barr virus infection were the major upregulated biological pathways in the C4 group (Figures 6A, E). The gene discussed is AKT1; the disease is Epstein-Barr virus infection.