The factors that control this unusual phenotype are currently unknown, but markedly altered NKp30 expression is commonly associated with infection, leading to alterations in dendritic cell (DC)/NK cell crosstalk, as described in HIV infections and HCV (Mavilio et al., 2006; Holder et al., 2013; Lucar et al., 2019). The gene discussed is NCR3; the disease is HIV infectious disease.