Based on the fine-tuned balance between inhibitory and activating NK cell receptors, early reports suggested that the increase in the inhibitory NKG2A receptor could contribute to the dysfunctional state of NK cells associated with COVID-19 (Gallardo-Zapata and Maldonado-Bernal, 2022), in contrast to our study and the results from other teams where no modulation of NKG2A was observed (Maucourant et al., 2020). Here, KLRD1 is linked to COVID-19.