1. CRSwNP groupTh17 CD4+CCR6+: Well-controlled vs Uncontrolled (13.28 ± 5.96 vs 7.16 ± 4.89, p = 0.046)2. CRSwNP group double negative Th17 CD4-CD8-CCR6+ cells: Uncontrolled vs Well-controlled (12.20 vs 5.40; p = 0.01)3. CRSsNP group cytotoxic CD3+CD8+ cells: Uncontrolled vs Well-controlled (79.86 ± 7.86 vs 52.95 ± 28.17, p = 0.045)4. CRSsNP group double negative CD4-CD8- cells: Well-controlled vs. Uncontrolled (46.93 ± 28.29 vs 20.70 ± 7.59, p = 0.019). The gene discussed is CD4; the disease is chronic rhinosinusitis without nasal polyps.