CD4 and chronic rhinosinusitis without nasal polyps: 1. The Th17 CD4 +CCR6+ cell to predict well-controlled CRSwNP.2.Double negative T17 CD4-CD8-CCR6+ cell (also capable of IL-17 production) predicted uncontrolled CRSwNP.3. In CRSsNP being cytotoxic type of inflammation the Tc CD8+ cell predicted the uncontrolled disease.4. The double negative CD4-CD8- predicted the well-controlled CRSsNP.