Surprisingly, Fibin-TG mice after TAC showed no differences compared to banded wildtype mice in terms of left ventricular hypertrophy (Figures 5A,B, Figure 5D–E) but a significant increase of lung weight to body weight ratio (n = five to eight per group, Figure 5C) indicating more pronounced heart failure compared to WT mice after TAC. This evidence concerns the gene FIBIN and heart failure.