NLRX1 has been linked with negative regulation of NF-κB signaling and subsequent protection against tumorigenesis and disease burden in gastric cancer cells challenged with Helicobacter pylori, intestinal organoid models of colonic tumorigenesis, AOM/DSS-induced models of colitis-associated cancer and sporadic colon cancer models in Apcmin/+ mice, urethane-induced histiocytic carcinoma, and human gastric cancer samples (28, 30, 37, 48, 49). This evidence concerns the gene NFKB1 and infectious otitis media.