To elucidate what general functions NLRX1 performs when it is expressed in pancreatic cancer cells, we generated Pan02 cells to either overexpress or knockdown NLRX1, as well as their respective controls (Pan02OE, Pan02OE-CTL, Pan02KD, Pan02KD-CTL; Figure 1A). The gene discussed is NLRX1; the disease is familial pancreatic carcinoma.