OIP5 and pulmonary arterial hypertension: In module1, we found the regulated relationship among hub nodes OIP5-AS1-has-mir-153-3p-CREBBP, and in module2 we identified ceRNA relationship NUTM2A-AS1-hsa-mir-107-PDE4D, iloprost is a small molecule drug that was used to treat pulmonary arterial hypertension (PAH) through regulated target gene PDE4D [37].