LMFLNC also revealed several potential metabolite-disease interactions, such as “Cortisol (HMDB0000063),” relating to “21-Hydroxylase deficiency,” and “3-Hydroxybutyric acid (HMDB0000011)” and “Acetoacetic acid (HMDB0000060),” both relating to “3-Hydroxy-3-methylglutaryl-CoA lyase deficiency.” This evidence concerns the gene HMGCL and classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency.