Patients with IRGN and pauci-immune GN had the lowest median estimated glomerular filtration rate (eGFR) at the time of biopsy, whereas patients with membranous nephropathy and focal segmental glomerulosclerosis (FSGS) had the highest median urine albumin-to-creatinine ratio (ACR). The gene discussed is ALB; the disease is focal segmental glomerulosclerosis.