TGF-β regulates the differentiation, proliferation, hypertrophy, migration, and apoptosis of intraglomerular and tubular cells, regulates remodeling of the extracellular matrix, and promotes interstitial and glomerular fibrosis and the development of glomerulosclerosis (Böttinger 2007; Blobe et al. 2000). This evidence concerns the gene TGFB1 and glomerulosclerosis.