However, while we found CACNB3 expression levels significantly decreased in (1) mTLE hippocampus compared to temporal lobe neocortex (Fig. 2A) and (2) mTLE hippocampus compared to non-epilepsy control subjects (Fig. 2A), Lin et al. found them globally slightly increased throughout the brains of cacnb4lh homozygote mice compared to controls [38]. Here, CACNB3 is linked to epilepsy.