Interestingly although not significant, we found CACNB3 expression levels increased in hippocampus compared to those in temporal lobe neocortex in non-epilepsy control subjects (Fig. 2A), supporting our initial assumption that mTLE CACNB3 expression level decrease in hippocampus compared to temporal lobe neocortex was related to disease. This evidence concerns the gene CACNB3 and epilepsy.