MAPT and Alzheimer disease: Data show that SARK and HMW tau have similar seeding activities in this specific assay whether SARK tau was sonicated or not (Fig. 2b), and this is consistent among our eight AD cases (average seeding ratio between HMW and non-sonicated SARK tau samples = 1.16; average seeding ratio between HMW and sonicated SARK tau samples = 1.05).