GNRH1 and colon adenocarcinoma: Stratified into different forms of ADT, there was a significantly increased risk of developing adenocarcinoma of the colon after exposure to AA (HR 1.29 [95% CI 1.04–1.60]) and GnRH + flare (HR 1.29 [95% CI 1.07–1.56]), but no significant association after exposure to GnRH (HR 1.29 [95% CI 0.91–1.83]), Orchiectomy (HR 1.42 [95% CI 0.89–2.27]), or Total Androgen Blockade (TAB) (HR 0.70 [95% CI 0.26–1.88]), (Table 2 A).