There seems to be a relationship between androgens (and therefore ADT) and the development of CRC but this relationship seems to be far more complex and involve both direct mechanisms (androgen receptors) and indirect mechanisms such as stress hormone levels, the innate immune system, bile as well as various risk factors including type 2 diabetes mellitus and metabolic syndrome or a combination of both acting in synergy [59]. The gene discussed is AR; the disease is metabolic syndrome.