At present, there are no specific experimental results to prove that MORN2 domain-containing proteins enhance the adhesion and invasion of bacteria, and an in-depth study of the function and mechanism of MORN2 domain-containing proteins would be of great significance for revealing the mechanism of the interaction between F. nucleatum and the host and for providing new clues for preventing and treating colorectal cancer (15). The gene discussed is MORN2; the disease is colorectal cancer.