Meanwhile, some ferroptosis inhibitors, such as vitamin E and desferrioxamine (DFE) have shown clinical benefits for the patients with AD.[171, 172] Loss of Fpn induces memory impairment by promoting ferroptosis in AD.[173] Fpn was downregulated in the brains of APPswe/PS1dE9 mice as an AD mouse model and AD patients. This evidence concerns the gene SLC40A1 and Alzheimer disease.