GPX4 and Alzheimer disease: Aβ decreased the expression of GPX4 and SLC7A11 and increased the level of TfR, suggesting ferroptosis are involved in Aβ neurotoxicity.[176] ORMDL3 gene, a susceptibility gene closely related to the occurrence of childhood asthma, promote AD through inducing ferroptosis by PERK/ATF4/HSPA5 signaling pathway.[177]