GPX4 and amyotrophic lateral sclerosis: Mutant SOD1 promotes ferroptosis via generating TfR1‐imported excess free iron, decreasing GSH, upregulating ALOX15, and inactivating GCH1 and GPX4 in ALS.[243] The study also showed that a highly conserved “cyclin‐like” protein, speedy/RINGO cell cycle regulator family member A (SPY1) resists ferroptosis by upregulating GCH1/BH4 and downregulating TfR1 in ALS.[243]