Moreover, a reduction of brain GPX4 level was observed in AD mice.[213] Inhibition of GPX4 decreases the sensitivity of brain to ferroptosis in AD pathogenesis.[63] Overexpression of GPX4 protects cortical neurons against Aβ‐induced cytotoxicity through suppressing LPO.[214] Ablation of GPX4 can cause a neuronal loss in the hippocampal regions in neonatal[23] and adult mice,[215] accompanied by elevated activation of astrocytes,[215] suggesting an suppressive function of GPX4 in neurodegenerative disorders. This evidence concerns the gene GPX4 and Alzheimer disease.