ACSL4 and brain ischemia: cPLA2α is increased after cerebral ischemia, and its knockdown can significantly decrease LPO and brain injury.[260, 271, 272, 273] Ischemic stroke upregulate ACSL4.[251, 266, 274, 275, 276, 277] Overexpression of ACSL4 aggravates ischemic brain damage, while silencing ACSL4 protects mouse brain against ischemia‐induced injury through inhibiting ferroptosis.[274]