SNX5 and Parkinson disease: Overall, SNX5 functions as an inducer of ferroptosis in PD.[137] This observation was corroborated by study from the same group, which reported SNX5 promotes ferroptosis in the PD model.[138] Mutations and increased leucine‐rich repeat kinase 2 (LRRK2) kinase activity are associated with both familial and idiopathic PD pathology.