PIK3CA and cancer: Under in vitro or immunodeficient in vivo conditions, ANO1 knockdown evidently suppressed GC's proliferation/migration/invasion and peritoneal/liver/lung metastasis, suggesting ANO1 itself plays a cancer promotive role independent of the immune system, which might be due to ANO1's function in activating PI3K‐Akt signaling and inhibiting ferroptosis in cancer cells.