Comparable to the results in immunodeficient human cancer CDXs, ANO1 knockdown reduced the growth of CT26 CDXs (Figure 4B), paired with increased CD8/granzyme B and decreased PD‐L1 IHC staining in xenograft tumors (Figure 4C,D), suggesting a higher infiltration of cytotoxic CD8+ T cells in TIME. This evidence concerns the gene CD8A and cancer.