PIK3CA and gastric cancer: On GC/CRC cellular level, PI3K‐Akt pathway inhibitor Dactolisib suppressed the upregulation of TGF‐β induced by ANO1 overexpression (Figure 8N and Figure S3S, Supporting Information), while the repression of TGF‐β expression/secretion by ANO1 knockdown were rescued by ferroptosis inhibitor Fer‐1 (Figure 8O,P and Figure S3T,U, Supporting Information), indicating TGF‐β production was regulated by the ANO1‐PI3K‐Akt‐ferroptosis axis.