On GC/CRC cellular level, PI3K‐Akt pathway inhibitor Dactolisib suppressed the upregulation of TGF‐β induced by ANO1 overexpression (Figure 8N and Figure S3S, Supporting Information), while the repression of TGF‐β expression/secretion by ANO1 knockdown were rescued by ferroptosis inhibitor Fer‐1 (Figure 8O,P and Figure S3T,U, Supporting Information), indicating TGF‐β production was regulated by the ANO1‐PI3K‐Akt‐ferroptosis axis. Here, AKT1 is linked to colorectal carcinoma.