Epidermal growth factor (EGF) receptors are commonly dysregulated in human cancers.(17) Accordingly, enhanced expression of HER2 serves as a biomarker and prognostic predictor for BC.(18) A previous study considering sex, age, and BMI in non-cancerous individuals suggested an association of enhanced HER2 expression with insulin resistance, type 2 diabetes mellitus, and IGFR.(19) Data from our study revealed 16% of sedentary women to be elderly, 76% to be obese, and 64% with no comorbidities, all of which serve as important factors for enhanced HER2 expression. This evidence concerns the gene IGF1R and Insulin resistance.