( 50 ) We found similar LIU in the spleen of all animals; however, perifosine-treated animals presented a decreased number of AML cells per LIU, which corroborated with the results of decreased spleen weight and indicated that AKT inhibition may not interfere with cellular mechanisms related to infiltration, such as migration and adhesion. The gene discussed is AKT1; the disease is acute myeloid leukemia.