The majority of ILC tumors express hormone receptors such as estrogen receptors (ER), progesterone receptors (PR) but they less commonly exhibit human epidermal growth factor receptor-2 (HER-2) overexpression or amplification.5 Data about prognosis of ILC vary substantially; studies have demonstrated better6,7, the same8, and worse long-term overall survival (OS) in comparison to unselected invasive breast cancers.9 Here, ESR1 is linked to invasive breast carcinoma.