However, the reported rates of posthepatectomy liver failure are from 2.6 to 16%.5,25,27–28 This wide range may also be due to several definitions of it.31 The most commonly used definitions were the following: peak bilirubin > 7 mg/dL32, the “50–50” criteria (50% of normal for the prothrombin index and 50 μmol/L for bilirubin on postoperative day 5)33, and the definition by the ISGLS used in this study.14 This evidence concerns the gene F2 and Hepatic failure.