LIN28B and its paralog LIN28A are well‐known cancer stem cell markers and have been demonstrated to drive growth and metastasis in several adult cancers, including breast, ovarian, esophageal, and pancreatic, as well as in pediatric neural tumors such as embryonal tumor with multilayered rosettes (ETMR), atypical teratoid/rhabdoid tumor (AT/RT), and neuroblastoma [6, 7, 8, 9, 10, 11, 12]. The gene discussed is LIN28B; the disease is neuroblastoma.