CX3CR1 and Anxiety: Monocytes are implicated in tissue repair in various pathologies.11,48 Our study aimed to investigate role of non-classical CX3CR1 monocytes in cSVD pathobiology and therapy, with an emphasis on hippocampus, a structure critically involved in memory and anxiety.6,41,49 Herein, we performed a longitudinal analysis of structural damage and infiltration of CX3CR1GFP/+ monocytes 3 and 7 days as well as 1 month after cSVD.